Search on: KETOL-ACID REDUCTOISOMERASE 
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Descriptor English:   Ketol-Acid Reductoisomerase 
Descriptor Spanish:   Cetoácido Reductoisomerasa 
Descriptor Portuguese:   Cetol-Ácido Redutoisomerase 
Tree Number:   D08.811.682.047.820.487
Definition English:   An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89. 
History Note English:   2006(1980); use VALERATES 1970-1979 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50599 
Unique Identifier:   D050540 

Occurrence in VHL:
 

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